Is There a Long-Term Risk for Donors With Heterozygous MEFV Mutation After Kidney Donation?

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Karakose S., Erdogmus S., Akturk S., Tuzuner A., Sengul Ş., KEVEN K.

Transplantation proceedings, vol.49, no.3, pp.399-402, 2017 (SCI-Expanded, Scopus)

• Publication Type: Article / Article
• Volume: 49 Issue: 3
• Publication Date: 2017
• Doi Number: 10.1016/j.transproceed.2017.01.012
• Journal Name: Transplantation proceedings
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.399-402
• Ankara University Affiliated: Yes

Abstract

Background. Familial Mediterranean fever (FMF) is an autosomal-recessive autoinflammatory disorder manifested severely by systemic amyloidosis. It has been hypothesized that heterozygous carriers may also have susceptibility to certain symptoms or even diseases. Because the living kidney donors of patients with FMF are generally relatives of the kidney recipients, there is a high possibility that the donors will have a heterozygous mutation of the FMF gene. The goal of this study was to investigate the long-term kidney function of donors who are carriers of the Mediterranean fever (MEFV) gene.