Akademik Veri Yönetim Sistemi
Turkiye Klinikleri Journal of Medical Sciences, cilt.25, sa.3, ss.412-420, 2005 (SCI-Expanded, Scopus, TRDizin)
Recent studies show that adipose tissue is not only a passive energy store, but also an active endocrine organ. White adipose tissues store excess energy as triglycerides. The stored energy is released rapidly to the circulation when it was needed. Adipose tissue is the body's largest reservoir of fuel. The storage and mobilization of energy is regulated by hormonal signals including insulin, catecholamines and glucocorticoids. Adipocytes secrete a number of substances such as leptin, resistin, tumor necrosis factor-α (TNF-α), adiponectin, adipsin, interleukin-6 (IL-6), plasminoen activator-inhibitor-1 (PAI-1), transforming growth factor-β (TGF-β), angiotensinogen, acylation-stimulating protein (ASP), prostaglandins 12 and F2α (PGI2 and PGF2α), and insulin-like growth factor I (IGF-I). Leptin regulates energy homeostasis and informs the hypothalamus of the status of body fat stores. Resistin might contribute to peripheral insulin sensitivity and insulin resistance. TNF-α interferes with insulin receptor signaling and causes the development of insulin resistance in the obese. Adiponectin may play a role the pathogenesis of familial combined hyperlipidemia and it is associated with insulin resistance. Adipsin has a part in adipose tissue metabolism. IL-6 has functions related to body defense mechanisms as well as glucose and lipid metabolism. PAI-1 is an important inhibitor of the fibrinolytic system. TGF-α regulates biological responses such as proliferation, differentiation, and apoptosis. Angiotensinogen is a precursor of angiotensin II, which is a regulator of blood pressure and electrolyte homeostasis. ASP increases the rate of triacylglycerol synthesis in adipose tissue. IGF-I stimulates proliferation of a wide variety of cells and mediates many effects of growth hormone. PGI2 and PGF2α play roles in regulatory functions such as inflammation and blood clotting, ovulation menstruation and acid secretion. Adipose tissue influences the function of many systems through all these products. Copyright © 2005 by Türkiye Klinikleri.