Macroporous Surgical Mesh from a Natural Cocoon Composite

Chen Y., Zang L., Koc-Bilican B., Bilican I., Holland C., CANSARAN DUMAN D., ...More

ACS SUSTAINABLE CHEMISTRY & ENGINEERING, vol.10, no.18, pp.5728-5738, 2022 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 10 Issue: 18
  • Publication Date: 2022
  • Doi Number: 10.1021/acssuschemeng.1c06941
  • Journal Name: ACS SUSTAINABLE CHEMISTRY & ENGINEERING
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CAB Abstracts, Chemical Abstracts Core, Compendex
  • Page Numbers: pp.5728-5738
  • Keywords: sustainable material, fibroin, sericin, biocompatibility, surgical mesh, tissue engineering, SILK FIBROIN SCAFFOLD, ABDOMINAL-WALL, HERNIA REPAIR, ENZYMATIC DEGRADATION, MECHANICAL-PROPERTIES, CELL-ADHESION, SERICIN, BIODEGRADATION, RECONSTRUCTION, BIOMATERIALS
  • Ankara University Affiliated: Yes

Abstract

Recently, traditional polymer-based surgical mesheshave drawn unwanted attention as a result of host tissuecomplications arising from infection, biocompatibility, andmechanical compatibility. Seeking an alternative solution, wepresent a hierarchically structured nanofibrous surgical meshderived from the naturally woven cocoon of the Japanese giantsilkworm, termed MothMesh. We report that it displays non-toxicity, biocompatibility, suitable mechanical properties, andporosity while showing no adverse effect in animal trials andeven appears to enhance cell proliferation. Hence, we assert thatthe use of this natural material may provide an effective andimproved alternative to existing synthetic meshes