Effects of different doses of epidural midazolam on spinal somatosensory evoked potentials

Cicek S., Attar A., Tuna H., Kecik Y., Egemen N.

ACTA NEUROCHIRURGICA, vol.142, no.8, pp.921-927, 2000 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 142 Issue: 8
  • Publication Date: 2000
  • Doi Number: 10.1007/s007010070079
  • Journal Name: ACTA NEUROCHIRURGICA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.921-927
  • Keywords: Spinal Somatosensory evoked potentials, midazolam, POSTERIOR TIBIAL NERVE, DERMATOMAL STIMULATION, INTRATHECAL MIDAZOLAM, MEDIATED ANALGESIA, CORD, BUPIVACAINE, RABBIT, RAT, NEUROTOXICITY, RECEPTORS
  • Ankara University Affiliated: No

Abstract

The aim of this study is to find out the effects of different doses of midazolam, when used epidurally, on somatosensory evoked potentials (SEP) by delaying neuronal conduction. Thirty two New Zeland albino male rabbits were divided into four groups. All rabbits were anesthetised with ketamine and xylasine combination and atracurium was used as muscle relaxant. 10 mg/kg/hr ketamine infusion was used for maintenance of anesthesia. After insertion of the epidural catheter surgically; Group 1 received 1.5 ml isotonic saline (Control), Group 2 received 150 mu g/kg, Group 3 received 250 mu g/kg, and Group 4 received 500 mu g/kg midazolam epidurally. With the stimulation of sciatic nerve, SEP records were recorded From the epidural space. Records were received before the injection of the drug, and 20, 40, 60 minutes after injection of the drug.