Synthesis and potent antimicrobial activity of some novel 4-(5,6-dichloro-1H-benzimidazol-2-yl)-N-substituted benzamides
ARCHIV DER PHARMAZIE, vol.337, no.10, pp.556-562, 2004 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 337 Issue: 10
- Publication Date: 2004
- Doi Number: 10.1002/ardp.200400884
- Journal Name: ARCHIV DER PHARMAZIE
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.556-562
- Keywords: H-benzimidazole, benzamide, antifungal and antibacterial activity, Turkey methicillin-resistant staphylococcus aureus, methicillin-resistant staphylococcus, epidermidis, BENZIMIDAZOLES, ANTIBACTERIAL
- Ankara University Affiliated: Yes
Abstract
A series of 4-(5,6-dichloro-1H-benzimidazol-2-yl)-N-substituted benzamides were synthesized and evaluated for antibacterial and antifungal activities against Staphylococcus aureus, methicillin-resistant S. aureus (MRSA), methicillin-resistant S. epidermis (MRSE), Enterococcus faecalis, Escherichia coli and Candida albicans. Certain compounds inhibit bacterial growth with low MIC values (mug/mL). Among them, compounds 10 and 11 exhibited the greatest antibacterial activity with MIC values of 3.12 mug/mL against S. aureus, MRSA and MRSE.