Derivative ratio spectrophotometry and differential derivative spectrophotometric determination of isoniazid and pyridoxine hydrochloride in dosage forms

Erk N.

SPECTROSCOPY LETTERS, cilt.34, sa.6, ss.745-761, 2001 (SCI-Expanded, Scopus) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 34 Sayı: 6
  • Basım Tarihi: 2001
  • Doi Numarası: 10.1081/sl-100107897
  • Dergi Adı: SPECTROSCOPY LETTERS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.745-761
  • Anahtar Kelimeler: isoniazid, pyridoxine hydrochloride, simultaneous determination, ratio-spectra derivative spectrophotometric, differential derivative spectrophotometry, pharmaceutical dosage formulations, PHARMACEUTICAL FORMULATIONS, RIFAMPICIN, MIXTURES, ASSAY, CHROMATOGRAPHY, HYDRAZINE, SODIUM, DRUGS
  • Ankara Üniversitesi Adresli: Evet

Özet

Derivative ratio spectrophotometric and differential derivative spectrophotometric methods, for the determination of isoniazid and pyridoxine hydrochloride in pharmaceutical dosage forms (tablets) is described. The first method depends on ratio derivative spectra spectrophotometry where isoniazid and pyridoxine hydrochloride were determined by the measurement of the first derivative ratio spectra of amplitudes (Abs.) at 250.7 and 305.8 nm, respectively. The other method, is based on differential derivative spectrophotometry for the simultaneous determination of isoniazid and pyridoxine hydrochloride in binary mixture without any pre-treatment by measuring the DeltaD(1) values.