Synthesis and antimicrobial activity of some 5-[2-(morpholin-4-yl)acetamido] and/or 5-[2-(4-substituted piperazin-1-yl)acetamido]2-(p-substituted phenyl)benzoxazoles

Temiz-Aripaci O., Ozdemir A., Yalcin I., YILDIZ İ., Aki-Sener E., Altanlar N.

ARCHIV DER PHARMAZIE, cilt.338, sa.2-3, ss.105-111, 2005 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 338 Sayı: 2-3
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1002/ardp.200400923
  • Dergi Adı: ARCHIV DER PHARMAZIE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Index Chemicus (IC)
  • Sayfa Sayıları: ss.105-111
  • Anahtar Kelimeler: benzoxazoles, antibacterial activity, antifungal activity, morpholine aceteamide, piperazine acetamide, REVERSE-TRANSCRIPTASE INHIBITORS, MICROBIOLOGICAL ACTIVITY, 2-PYRIDINONE DERIVATIVES, BENZIMIDAZOLES, BENZOXAZOLES, UK-1, BENZOTHIAZOLES, ANALOGS, AGENTS, OXAZOLO(4,5-B)PYRIDINES
  • Ankara Üniversitesi Adresli: Evet

Özet

In this study, a series of twelve novel 5-[2-(morpholin-4-yl)acetamido] and/or 5-[2-(4-substituted piperazine-1-yl)acetamido]-2-(p-substituted phenyl]benzoxazole derivatives have been synthesized and their structures were confirmed by IR, H-1 NMR, and mass spectral data. These compounds were prepared by reacting 5-(2-chloroacetamido)-2-(4-p-substituted-phenyl)benzoxazoles, which were obtained by using 5-amino-2-[p-substituted-phenyl]benzoxazoles with chloroacetyl chloride, in the presence of morpholine or I-substituted piperazines. All synthesized compounds 3-14 were tested by using the method of twofold serial dilution technique for in vitro activities against certain strains of Gram-positive, Gram-negative bacteria as well as the yeasts Candida albicans, Candida krusei, and Candida glabrata in comparison with standard drugs. Microbiological results showed that the newly synthesized compounds possessed a broad spectrum of activity, showing MIC values of 3.12-50 mu g/mL against the Candida species.