Atıf İçin Kopyala
Erdoğmuş E., İpek Tekneci S., Gümüşel B., Duydu Y., Üstündağ A.
ANKARA UNIVERSITESI ECZACILIK FAKULTESI DERGISI, cilt.48, sa.2, ss.15, 2024 (Scopus)
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Yayın Türü:
Makale / Tam Makale
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Cilt numarası:
48
Sayı:
2
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Basım Tarihi:
2024
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Doi Numarası:
10.33483/jfpau.1428739
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Dergi Adı:
ANKARA UNIVERSITESI ECZACILIK FAKULTESI DERGISI
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Derginin Tarandığı İndeksler:
Scopus, Central & Eastern European Academic Source (CEEAS), EMBASE, TR DİZİN (ULAKBİM)
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Sayfa Sayıları:
ss.15
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Ankara Üniversitesi Adresli:
Evet
Özet
Objective: This study aimed to determine the DNA damage induced by Bisphenol A (BPA) and Bisphenol S (BPS) on MCF7 cell line.
Material and Method: DNA damage was determined by COMET assay in MCF7 cell line at 0.1, 0.5, 1, 5, 10 and 50 μM concentrations of BPA and BPS.
Result and Discussion: All BPA and BPS concentrations studied (0.1, 0.5, 1, 5, 10 and 50 μM) significantly induced DNA damage on MCF7 cell line compared with control (p<0.05). BPS significantly induced DNA damage more than BPA at the 3 highest concentrations studied (5, 10 and 50 μM) (p<0.05). This study shows that bisphenol derivatives can also cause DNA damage like BPA.