Strain-Specific Impact of Fusobacterium nucleatum on Neutrophil Function

Kurgan Ş., Kansal S., Nguyen D., Stephens D., Koroneos Y., Hasturk H., ...Daha Fazla

JOURNAL OF PERIODONTOLOGY, cilt.88, sa.4, ss.380-389, 2017 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 88 Sayı: 4
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1902/jop.2016.160212
  • Dergi Adı: JOURNAL OF PERIODONTOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.380-389
  • Anahtar Kelimeler: Apoptosis, cytokines, Fusobacterium nucleatum, neutrophils, phagocytosis, superoxides, LOCALIZED AGGRESSIVE PERIODONTITIS, TOLL-LIKE-RECEPTORS, PORPHYROMONAS-GINGIVALIS, POLYMORPHONUCLEAR LEUKOCYTES, ORAL BACTERIUM, F-NUCLEATUM, CELL-DEATH, SUBSP-NOV, INFLAMMATION, DISEASES
  • Ankara Üniversitesi Adresli: Evet

Özet

Background: Neutrophil function is critical for initiation and progression of infecto-inflammatory diseases. Key quorum-sensing plaque bacteria, such as Fusobacterium nucleatum, act as bridging species between early and late colonizer pathogens, such as Porphyromonas gingivalis, as the biofilm ages and periodontal inflammation increases. This study is designed to determine impact of different F. nucleatum strains on neutrophil function.