Akademik Veri Yönetim Sistemi
STP PHARMA SCIENCES, cilt.8, sa.3, ss.203-208, 1998 (SCI-Expanded)
Three new methods were used for the quantitative analysis of a tablet formulation containing pseudoephedrine hydrochloride and triprolidine hydrochloride:first derivative spectrophotometry, ratio spectra derivative spectrophotometry and Vierordt's method lit the first method dA/d lambda values were measured at 264.0 am for pseudoephedrine hydrochloride and at 291.8 nm for triprolidine hydrochloride in the first derivative, and the calibration graphs were linear from 200 to 1200 mu g/ml for pseudoephedrine hydrochloride and 10 to 50 mu g/ml for triprolidine hydrochloride. In the second method, the calibration graphs for 120 to 2200 mu g/ml pseudoephedrine hydrochloride and for 5 to 50 mu g/ml triprolidine hydrochloride were obtained by measuring the analytical signals at 266.3 nm for pseudoephedrine hydrochloride and at 275.4 nm for triprolidine hydrochloride. In the third method, absorptivity A(1)(1) (%1, 1 cm) values were calculated by using the absorbances measured at 256.8 nm and 278.1 nm in the zero-order spectra for each of active compounds in the binary mixture. The quantities of both compounds were calculated by means of equations with two unknowns using the A(1)(1) (%1, 1 cm) values. The methods were applied to determine both compounds in a pharmaceutical product.