Akademik Veri Yönetim Sistemi
EUROPEAN JOURNAL OF GERIATRICS AND GERONTOLOGY, sa.3, ss.200-207, 2024 (ESCI)
Objective: Nocturnal hypertension (HT) predicts HT-related end-organ damage and cardiovascular mortality, with a complex pathophysiology involving multiple factors. Vitamin D is considered an emerging contributor. This study examined the relationship between vitamin D level and nocturnal HT in older adults with HT. Materials and Methods: This cross-sectional study examined 219 patients aged >= 60 years, who underwent ambulatory blood pressure (BP) monitoring. An average nighttime systolic BP >= 120 mm Hg and/or diastolic BP >= 70 mm Hg was diagnosed as nocturnal HT. Vitamin D insufficiency was defined as serum 25 (OH) vitamin D levels 30 ng/mL. Results: The prevalence of nocturnal HT was 69.9% among older hypertensive adults. In the group with nocturnal HT, there was a significantly higher percentage of patients with vitamin D insufficiency than those without (89.5% vs. 72.7%; p=0.002). A reverse linear relationship was noted between the quartiles of 25 (OH) vitamin D and the occurrence of nocturnal HT. The percentage of individuals with nocturnal HT declined as the quartiles of 25 (OH) vitamin D increased (p-value for trend = 0.015). In the multivariate logistic regression analysis, after accounting for age, Charlson's comorbidity index, and average daytime systolic BP values, vitamin D insufficiency was linked to a significantly higher likelihood of nocturnal HT (OR=4.92, 95% CI=1.66-14.61, p=0.004). Conclusion: Vitamin D insufficiency may contribute to the development of nocturnal hypertension in older hypertensive adults.