Evaluation of cytotoxic effects on ethereal extracts of some selected liverworts

ÖNDER A., Özenoğlu H.

Fabad Journal of Pharmaceutical Sciences, cilt.44, sa.2, ss.119-125, 2019 (Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 44 Sayı: 2
  • Basım Tarihi: 2019
  • Dergi Adı: Fabad Journal of Pharmaceutical Sciences
  • Derginin Tarandığı İndeksler: Scopus
  • Sayfa Sayıları: ss.119-125
  • Anahtar Kelimeler: Cytotoxicity, GC/MS, Hepaticae, Liverworts, Marchantiophyta, MTT
  • Ankara Üniversitesi Adresli: Evet

Özet

© 2019 Society of Pharmaceutical Sciences of Ankara (FABAD). All rights reserved.The liverworts are interesting examples of the spore-forming plants with distinguishing chemical diversity of the secondary metabolites and a wide range of biological activities. In this study, Turkish liverworts have been investigated for their cytotoxic activities as a preliminary screening. Therefore, the ether extracts of some selected Turkish liverworts such as Riccia fluitans L., Porella cordaeana (Huebener) Moore, Porella platyphylla (L.) Pfeiff., Corsinia coriandrina (Spreng.) Lindb., Mannia androgyna (L.) A. Evans, Reboulia hemisphaerica (L.) Raddi, Plagiochasma rupestre (J.R. Forst et G. Forst) Steph. and Targionia hypophylla L. have been investigated by MTT assay using HeLa (Human cervical cancer cells), Sp2/0 (Mouse myeloma cells), YAC-1 (Mouse lymphoma cells) cell lines for the evaluation of cytotoxic activities. The most active extracts were determined, and the results were given as % inhibitions rates. The results compared with the phytochemical constituents of the liverworts that have been investigated previously on gas chromatography/mass spectroscopy (GC/MS).