New Voltammetric Approach to the Quantitation of Paracetamol in Tablets and Syrup using Chemometric Optimization Technique
JOURNAL OF ANALYTICAL CHEMISTRY, cilt.74, sa.3, ss.296-305, 2019 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 74 Sayı: 3
- Basım Tarihi: 2019
- Doi Numarası: 10.1134/s1061934819030110
- Dergi Adı: JOURNAL OF ANALYTICAL CHEMISTRY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.296-305
- Anahtar Kelimeler: experimental design and optimization, gold nanoparticles, paracetamol, pencil graphite electrode, SPECTRA DERIVATIVE SPECTROPHOTOMETRY, CAPILLARY-ELECTROPHORESIS, CAFFEINE, BEHAVIOR, ACID
- Ankara Üniversitesi Adresli: Evet
Özet
A new voltammetric approach was developed for the determination of paracetamol in tablet and syrup samples using chemometric optimization. The method is based on the use of the gold nanoparticles-polyaniline (AuNPs-PA) modified pencil graphite electrode (PGE). Electrode system was fabricated by using the electrochemical reduction of gold on aniline modified pencil electrode to give gold nanoparticles. A 3(3) full factorial design was used to find optimal oxidation conditions of paracetamol on the AuNPs-PA-PGE. The optimal oxidation conditions of drug substance were found as -524 mV for the accumulation potential, 295 s for the accumulation time and pH 8.69 (for the phosphate buffer solution, 0.1 M). The determination of paracetamol was linear in the range of 2.0 x 10(-7)-6.0 x 10(-6) M with a detection limit of 5 x 10(-8) M. As a result, the proposed voltammetric approach gave satisfactory results for the determination of the related drug substance in tablets and syrup.