Akademik Veri Yönetim Sistemi
ZINC SIGNALING, 2ND EDITION, ss.139-164, 2019 (SCI-Expanded)
Zinc is an important micronutrient for mammalians, whereas free/labile zinc ion (Zn2+) level ([Zn2+](i)) in cells can be detrimental if it is over the physiological range. The cellular [Zn2+](i) is regulated by proteins, responsible for its influx (ZIP family) into cells or efflux (ZnT-family) from cells. In addition, it has been shown that there is a close relationship between cellular [Zn2+](i) and increasing oxidative stress, and both are also responsible for the dysregulation of the excitation/contraction coupling in the heart. Although age-dependent changes in the structure and function of the left ventricle are closely related to fibrosis, cellular evidence showed the importance of mitochondria as a potential target for aging medicine. However, several studies have shown that zinc supplementation provides important improvements in the maintenance of cardiovascular disorders, and it is needed to know the exact role of [Zn2+](i) and its transporters in aging heart function. Although there is very little information related to the role of Zn2+ transporters in mammalian aging, some studies have shown their importance in cardiovascular disorders including failing human heart. Since few studies examined the role of ZIP14 as an inflammation responsive transporter and amplified with aging, we demonstrated an important data on the ZIP14 status in organelles such as the sarcoplasmic reticulum and mitochondria in aging rat's ventricular cardiomyocytes. As a summary, we discussed our data in the light of literature data as well.