Akademik Veri Yönetim Sistemi
Journal de Pharmacie de Belgique, cilt.53, sa.3, ss.250, 1998 (SCI-Expanded)
Zuclopenthixol (ZPT), a new thioxanthene of high potency with general properties similar to the phenothiazine, chlorpromazine, is used for the treatment of schizophrenia and other psychoses. To our knowledge, there are no literature data on the electrooxidation of ZPT. In this study, the electrochemical behaviour of ZPT based on the oxidation at a glassy carbon electrode over pH range 1.5-6.5 in various supporting electrolytes. The nature of the supporting electrolyte had a strong effect on the voltammetric response. Under linear sweep voltammetry, ZPT gave rise to two well-defined, sharp oxidation peaks with the peak potentials of about + 1.1 and + 1.35 V (vs SCE) in 0.2 M H2SO4. For analytical purposes, the first anodic step was the more useful. The peak current was diffusion-controlled in the concentration range of 6×10-6 to 8×10-4M. The method for the determination of ZPT in different drug formulations (tablets, oral solutions) was established. With the knowledge of the voltammetric oxidation characteristic parameters as a function of pH, a reversed-phase HPLC method with electrochemical detection was also developed and applied to the pharmaceutical preparations.