Regenerative medicine for cardiovascular disorders-new milestones: Adult stem cells

AKAR A. R., Durdu S., Corapcioglu T., Ozyurda U.

ARTIFICIAL ORGANS, cilt.30, sa.4, ss.213-232, 2006 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 30 Sayı: 4
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1111/j.1525-1594.2006.00209.x
  • Dergi Adı: ARTIFICIAL ORGANS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.213-232
  • Anahtar Kelimeler: cell-based therapy, stem cell, angiogenesis, cardiac regeneration, bone marrow cells, plasticity, ENDOTHELIAL PROGENITOR CELLS, BONE-MARROW-CELLS, COLONY-STIMULATING FACTOR, SKELETAL MYOBLAST TRANSPLANTATION, CORONARY-ARTERY-DISEASE, ACUTE MYOCARDIAL-INFARCTION, BLOOD MONONUCLEAR-CELLS, REDUCED NEOVASCULARIZATION CAPACITY, HUMAN ADIPOSE-TISSUE, PERIPHERAL-BLOOD
  • Ankara Üniversitesi Adresli: Evet

Özet

Cardiovascular disorders are the leading causes of mortality and morbidity in the developed world. Cell-based modalities have received considerable scientific attention over the last decade for their potential use in this clinical arena. This review was intended as a brief overview on the subject of therapeutic potential of adult stem cells in cardiovascular medicine with basic science findings and the current status of clinical applications. The historical perspective and basic concepts are reviewed and a description of current applications and potential adverse effects in cardiovascular medicine is given. Future improvements on cell-based therapies will likely provide remarkable improvement in survival and quality of life for millions of patients with cardiovascular disorders.