Activating PPAR alpha Prevents Post-Ischemic Contractile Dysfunction in Hypertrophied Neonatal Hearts

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Lam V. H., Zhang L., Huqi A., Fukushima A., Tanner B. A., BEŞİKCİ A., ...Daha Fazla

CIRCULATION RESEARCH, cilt.117, sa.1, ss.41-51, 2015 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 117 Sayı: 1
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1161/circresaha.117.306585
  • Dergi Adı: CIRCULATION RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.41-51
  • Anahtar Kelimeler: heart failure, hypertrophy, metabolism, therapy, FATTY-ACID-METABOLISM, ENDOPLASMIC-RETICULUM STRESS, RECEPTOR-ALPHA, MYOCARDIAL PROTECTION, OVERLOAD HYPERTROPHY, BETA-OXIDATION, RAT-LIVER, FACTOR-I, EXPRESSION, MATURATION
  • Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
  • Ankara Üniversitesi Adresli: Evet

Özet

Rationale: Post-ischemic contractile dysfunction is a contributor to morbidity and mortality after the surgical correction of congenital heart defects in neonatal patients. Pre-existing hypertrophy in the newborn heart can exacerbate these ischemic injuries, which may partly be due to a decreased energy supply to the heart resulting from low fatty acid -oxidation rates.