Liquid-Phase Microextraction Approaches for Preconcentration and Analysis of Chiral Compounds: A Review on Current Advances
Critical Reviews in Analytical Chemistry, cilt.53, sa.8, ss.1623-1637, 2023 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Derleme
- Cilt numarası: 53 Sayı: 8
- Basım Tarihi: 2023
- Doi Numarası: 10.1080/10408347.2022.2038072
- Dergi Adı: Critical Reviews in Analytical Chemistry
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, Aqualine, Aquatic Science & Fisheries Abstracts (ASFA), Biotechnology Research Abstracts, Chemical Abstracts Core, Chimica, Communication Abstracts, Compendex, EMBASE, Environment Index, Geobase, MEDLINE, Metadex, Civil Engineering Abstracts
- Sayfa Sayıları: ss.1623-1637
- Anahtar Kelimeler: Chiral compounds, enantiomer separation, enantioselective metabolism, liquid-phase microextraction, toxicokinetic, toxicodynamic mechanisms, MODIFIED CAPILLARY-ELECTROPHORESIS, SOLVENT-BASED MICROEXTRACTION, SUPRAMOLECULAR SOLVENTS, HUMAN PLASMA, ENANTIOSELECTIVE ANALYSIS, CHROMATOGRAPHIC DETERMINATION, PROPRANOLOL ENANTIOMERS, AMLODIPINE ENANTIOMERS, GAS-CHROMATOGRAPHY, SAMPLE PREPARATION
- Ankara Üniversitesi Adresli: Evet
Özet
© 2022 Taylor & Francis Group, LLC.Chirality is a critical issue in pharmaceutics, forensic chemistry, therapeutic drug monitoring, doping control, toxicology, or environmental investigations as enantiomers of a chiral compound can exhibit different activities, i.e., one enantiomer can have the desired effect while the other one can be inactive or even toxic. To monitor enantioselective metabolism or toxicokinetic/toxicodynamic mechanisms in extremely low content in biological or environmental matrices, sample preparation is vital. The present review describes current status of development of liquid-phase microextraction approaches such as hollow fiber liquid-phase microextraction (HF-LPME), electromembrane extraction (EME), dispersive liquid-liquid microextraction (DLLME), and supramolecular solvent-based microextraction (SSME), used for sample preparation of enantiomers/chiral compounds. The advantages and limitations of the above techniques are discussed. Attention is also focused on chiral separation approaches commonly applied to study the stereo-selective metabolism or toxicokinetic/toxicodynamic mechanisms of enantiomers in the biological and environmental samples.