Reactivity of mixed organozinc and mixed organocopper reagents: 6. Nickel-catalyzed coupling of methylarylzincs with primary alkyl halides; an atom-economic aryl-alkyl coupling

Pekel Ö., Erdik E.

TETRAHEDRON LETTERS, cilt.52, sa.52, ss.7087-7090, 2011 (SCI-Expanded, Scopus) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 52 Sayı: 52
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1016/j.tetlet.2011.10.083
  • Dergi Adı: TETRAHEDRON LETTERS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Current Chemical Reactions (CCR)
  • Sayfa Sayıları: ss.7087-7090
  • Anahtar Kelimeler: Alkylarylzincs, Alkylation, Mixed diorganozincs, Triphenylphosphine
  • Ankara Üniversitesi Adresli: Evet

Özet

A nickel-catalyzed process for the cross-coupling of mixed arylzincs and primary alkyl halides has been developed. The reaction of a methylarylzinc with a primary alkyl halide in THF in the presence of NiCl2/PPh3 takes place with selective aryl transfer at room temperature in moderate yields. This protocol provides an atom-economic alternative to aryl-primary alkyl coupling using diarylzincs. (C) 2011 Elsevier Ltd. All rights reserved.