The effects of LXR agonist GW3965 on vascular reactivity and inflammation in hypertensive rat aorta

HAN S., BAL N. B., SADİ G., Usanmaz S. E., ULUDAĞ M. O., DEMİREL YILMAZ E.

LIFE SCIENCES, cilt.213, ss.287-293, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 213
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1016/j.lfs.2018.10.042
  • Dergi Adı: LIFE SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.287-293
  • Anahtar Kelimeler: Hypertension, Liver X receptors, GW3965, Inflammation, Aorta, ENDOTHELIAL DYSFUNCTION, QUERCETIN TREATMENT, OXIDATIVE STRESS, RECEPTOR, INVOLVEMENT, EXPRESSION, CELLS, CONTRACTION, INHIBITION, RESISTANCE
  • Ankara Üniversitesi Adresli: Evet

Özet

Aims: Liver X receptors (LXRs) play an important role in the regulation of cholesterol, fatty acid and glucose metabolisms together with inflammatory processes. In the present study, the effects of LXR agonist GW3965 on vascular reactivity and expression of functional proteins in DOCA-Salt induced hypertension were examined.