Polymorphisms of the IL-1 gene complex in coal miners with silicosis

Yucesoy B., Vallyathan V., Landsittel D., Sharp D., Matheson J., Burleson F., ...Daha Fazla

AMERICAN JOURNAL OF INDUSTRIAL MEDICINE, cilt.39, sa.3, ss.286-291, 2001 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 39 Sayı: 3
  • Basım Tarihi: 2001
  • Dergi Adı: AMERICAN JOURNAL OF INDUSTRIAL MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.286-291
  • Anahtar Kelimeler: silicosis, interleukin-1, polymorphism, epidemiology, genetics, INTERLEUKIN-1 RECEPTOR ANTAGONIST, NECROSIS-FACTOR-ALPHA, FIBROBLAST PROLIFERATION, ALOPECIA-AREATA, SEVERITY FACTOR, ASSOCIATION, CYTOKINES, DISEASE, EXPRESSION, MONOCYTES
  • Ankara Üniversitesi Adresli: Hayır

Özet

Background Silicosis is characterized by fibrosing nodular lesions that eventually develop into progressive pulmonary fibrosis. Pro-inflammatory cytokines, such as interleukin-l (IL-I), play a key role in the development of silicosis by regulating mediators which are responsible for lung injury, inflammation, and potentially fibrosis. To study whether functional single nucleotide polymorphisms (SNPs) located in the regulatory elements of genes coding for the IL-1 alpha, IL-1 beta, and IL-1 receptor antagonist (RA) cytokines are associated with silicosis, we examined 318 Caucasian cases confirmed histopathologically with pulmonary silicosis and 163 controls without any apparent inflammation or other pulmonary disease.