Polymorphisms of the IL-1 gene complex in coal miners with silicosis

Yucesoy B., Vallyathan V., Landsittel D., Sharp D., Matheson J., Burleson F., ...More

AMERICAN JOURNAL OF INDUSTRIAL MEDICINE, vol.39, no.3, pp.286-291, 2001 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 39 Issue: 3
  • Publication Date: 2001
  • Journal Name: AMERICAN JOURNAL OF INDUSTRIAL MEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.286-291
  • Keywords: silicosis, interleukin-1, polymorphism, epidemiology, genetics, INTERLEUKIN-1 RECEPTOR ANTAGONIST, NECROSIS-FACTOR-ALPHA, FIBROBLAST PROLIFERATION, ALOPECIA-AREATA, SEVERITY FACTOR, ASSOCIATION, CYTOKINES, DISEASE, EXPRESSION, MONOCYTES
  • Ankara University Affiliated: No

Abstract

Background Silicosis is characterized by fibrosing nodular lesions that eventually develop into progressive pulmonary fibrosis. Pro-inflammatory cytokines, such as interleukin-l (IL-I), play a key role in the development of silicosis by regulating mediators which are responsible for lung injury, inflammation, and potentially fibrosis. To study whether functional single nucleotide polymorphisms (SNPs) located in the regulatory elements of genes coding for the IL-1 alpha, IL-1 beta, and IL-1 receptor antagonist (RA) cytokines are associated with silicosis, we examined 318 Caucasian cases confirmed histopathologically with pulmonary silicosis and 163 controls without any apparent inflammation or other pulmonary disease.