Analysis of the correlation between sperm DNA integrity and conventional semen parameters in infertile men

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AYDOS O. S., Yukselten Y., Kaplan F., SUNGUROĞLU A., AYDOS K.

TURKISH JOURNAL OF UROLOGY, cilt.41, sa.4, ss.191-197, 2015 (ESCI) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 41 Sayı: 4
  • Basım Tarihi: 2015
  • Doi Numarası: 10.5152/tud.2015.98475
  • Dergi Adı: TURKISH JOURNAL OF UROLOGY
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.191-197
  • Anahtar Kelimeler: Male infertility, morphology, motility, sperm DNA damage, HUMAN SPERMATOZOA, FERTILIZING ABILITY, APOPTOTIC MARKERS, OXIDATIVE STRESS, CASPASE ACTIVITY, CELL APOPTOSIS, DAMAGE, FRAGMENTATION, QUALITY, POPULATION
  • Ankara Üniversitesi Adresli: Evet

Özet

Objective: A male factor is responsible in approximately 30-40% of couples receiving infertility treatment. Routinely, such couples undergo semen analysis including parameters such as sperm count, motility and morphology. Generally, the analysis of sperm DNA damage, shown to have a significant clinical importance by many studies, is recognized as an advanced test that is not included in routine infertility tests. Intracytoplasmic sperm injection (ICSI) method, commonly employed in the current infertility treatment protocols, lowers the fertilization rate, however, fertilization can occur even with a damaged DNA which is known to pose a risk in the subsequent pregnancy period. The relation between sperm morphology and the degree of sperm DNA damage has not yet been understood clearly. In this study, we aimed to investigate the association between routine semen analysis and sperm DNA integrity assay, another advanced but costly method.