Determining the persistence of maternally acquired antibodies to hepatitis A and varicella zoster during the first 2 years of life in Turkey

Begde F., ORHON F., GERÇEKER D., ULUKOL B., TOPÇU S., BAŞKAN S.

EUROPEAN JOURNAL OF PEDIATRICS, cilt.174, sa.7, ss.883-890, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 174 Sayı: 7
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1007/s00431-014-2484-2
  • Dergi Adı: EUROPEAN JOURNAL OF PEDIATRICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.883-890
  • Anahtar Kelimeler: Maternally acquired antibodies, Hepatitis A, Varicella, Vaccination, VACCINE RESPONSES, VIRUS, SEROPREVALENCE, KINETICS, RUBELLA, IMMUNOGENICITY, INFANTS, MEASLES, MUMPS, NEED
  • Ankara Üniversitesi Adresli: Evet

Özet

Vaccination should be timed to take into account the potential interference of maternal antibodies. The purpose of this study was to determine the persistence of maternally acquired antibodies to hepatitis A and varicella zoster in a group of healthy infants between 6 and 24 months of age. These infants were divided into four groups according to the age at the time of follow-up visits. The study group consisted of infants who were brought to the 6-month follow-up visit (group 1, n = 100), 12-month follow-up visit (group 2, n = 99), 18-month follow-up visit (group 3, n = 59), and 24-month follow-up visit (group 4, n = 59). Hepatitis A, varicella IgG, and IgM antibodies were analyzed qualitatively. Hepatitis A IgG seropositivity was determined as 71 % in group 1, 41.4 % in group 2, 0 % in group 3, and 8.5 % in group 4 (p < 0.001). Varicella IgG seropositivity was found to be 5 % in group 1, 4 % in group 2, 4 % in group 3, and 1 % in group 4 (p > 0.05).