Association of -174G/C interleukin-6 gene polymorphism with the risk of chronic lymphocytic, chronic myelogenous and acute myelogenous leukemias in Turkish patients

MUTLU P., Yalcin S., Elei P., Yildirim M., Cetin A. T., Avcu F.

Journal of B.U.ON., cilt.19, sa.3, ss.787-791, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 19 Sayı: 3
  • Basım Tarihi: 2014
  • Dergi Adı: Journal of B.U.ON.
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.787-791
  • Anahtar Kelimeler: -174G/C, IL-6, leukemia, single nucleotide polymorphisms, PROMOTER POLYMORPHISM, PLASMA-LEVELS, IL-6 GENE, IL6 GENE, DISEASE, INFLAMMATION, REGION
  • Ankara Üniversitesi Adresli: Evet

Özet

Purpose: The purpose of this study was to evaluate the relationship between -174G/C interleukin-6 (IL-6) gene promoter polymorphism and susceptibility to chronic lymphocytic (CLL), chronic myelogenous (CML) and acute myelogenous leukemia (AML) in Turkish patients.Methods: The frequencies of-174G/C polymorphism were studied in 23 unrelated CLL, 25 CML and 17 AML patients and 30 healthy individuals. Single nucleotide polymorphisms (SNPs) were genotyped by the PCR-RFLP method.Results: A higher prevalence of the C allele was found in CLL, CML and AML patients. However, there were no statistically significant differences regarding either the genotype or the allelic frequencies of the -174G/C polymorphism between CLL, CML and AML cases.Conclusions: These results indicate that C allele is associated with risk of CLL, CML and AML susceptibility in Turkish patients.