Association of -174G/C interleukin-6 gene polymorphism with the risk of chronic lymphocytic, chronic myelogenous and acute myelogenous leukemias in Turkish patients
Journal of B.U.ON., cilt.19, sa.3, ss.787-791, 2014 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 19 Sayı: 3
- Basım Tarihi: 2014
- Dergi Adı: Journal of B.U.ON.
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.787-791
- Anahtar Kelimeler: -174G/C, IL-6, leukemia, single nucleotide polymorphisms, PROMOTER POLYMORPHISM, PLASMA-LEVELS, IL-6 GENE, IL6 GENE, DISEASE, INFLAMMATION, REGION
- Ankara Üniversitesi Adresli: Evet
Özet
Purpose: The purpose of this study was to evaluate the relationship between -174G/C interleukin-6 (IL-6) gene promoter polymorphism and susceptibility to chronic lymphocytic (CLL), chronic myelogenous (CML) and acute myelogenous leukemia (AML) in Turkish patients.Methods: The frequencies of-174G/C polymorphism were studied in 23 unrelated CLL, 25 CML and 17 AML patients and 30 healthy individuals. Single nucleotide polymorphisms (SNPs) were genotyped by the PCR-RFLP method.Results: A higher prevalence of the C allele was found in CLL, CML and AML patients. However, there were no statistically significant differences regarding either the genotype or the allelic frequencies of the -174G/C polymorphism between CLL, CML and AML cases.Conclusions: These results indicate that C allele is associated with risk of CLL, CML and AML susceptibility in Turkish patients.