Steroidal Saponins from the Rhizomes of Ruscus hypophyllum

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Mimaki Y., Aoki T., Jitsuno M., Yokosuka A., KILIÇ C. S., Coskun M.

NATURAL PRODUCT COMMUNICATIONS, cilt.3, sa.10, ss.1671-1678, 2008 (SCI-Expanded, Scopus) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 3 Sayı: 10
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1177/1934578x0800301018
  • Dergi Adı: NATURAL PRODUCT COMMUNICATIONS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1671-1678
  • Anahtar Kelimeler: Ruscus hypophyllum, Liliaceae, spirostanol saponins, furostanol saponins, cholestane glycosides, HL-60 cells, UNDERGROUND PARTS, SPIROSTANOL SAPONIN, CYTOSTATIC ACTIVITY, HL-60 CELLS, ACULEATUS, GLYCOSIDES
  • Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
  • Ankara Üniversitesi Adresli: Evet

Özet

Phytochemical screening of the rhizomes of Ruscus hypophyllum (Liliaccae) has resulted in the isolation of five spirostanol saponins (1-5) including a new saponin (4) and nine furostanol saponins (6-14) including three new saponins (9-11), together with a known cholestane glycoside (15) and a new cholestane glycoside (16). The structures of the new compounds were determined on the basis of extensive spectroscopic analysis, including 2D NMR data, and chemical evidence. The spirostanol saponins 1, 2, and 5 showed moderate cytotoxic activity against HL-60 human promyelocytic leukemia cells.