Research Information System
European Congress of Radiology, Vienna, Austria, 28 February - 04 March 2018, pp.462
Purpose: In primary sclerosing cholangitis (PSC), peripheral vascular and / or
lymphatic drainage disturbances resulting from periductal inflammation of
peripheral bile ducts are seen as peripheral subcapsular triangular
hyperintense areas in T2-weighted images. In the progressive phase, fibrosis
may develop in this tissue of impaired perfusion. This study aims to compare
the tissue stiffness values of liver peripheral and central segments with MR
elastography based on T2 signal differences in liver parenchyma in patients
with PSC.
Methods and Materials: A total of 10 patients with PSC were included in this
study (5 males, 5 females, mean age 50.6 years, median age 49 years (range
38-59)). The stiffness values of the 1/3 peripheral section and the remaining
central section of the liver were measured on confidence map of MR
elastography (1.5 Tesla MR system). The 'Wilcoxon signed rank test' was used
to compare the peripheral and central measurements determined as mean
kPa.
Results: The median stiffness values were 4.3 kPa and 3.35 kPa in peripheral
and central sections, respectively. Significant difference between the peripheral
and central tissue stiffness values was detected (p=0.008).
Conclusion: In PSC, tissue stiffness in the periphery of the liver is greater than
in the central. This finding is consistent with the observation that ductal
dilatation, periductal inflammation and fibrosis are predominantly seen at the
periphery.