Photosensitive Rash in Association with Porphyrin Biosynthesis Possibly Induced by Docetaxel and Trastuzumab Therapy in a Patient with Metastatic Breast Carcinoma

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AKAY B. N., Unlu E., Buyukcelik A., Akyol A.

JAPANESE JOURNAL OF CLINICAL ONCOLOGY, cilt.40, sa.10, ss.989-991, 2010 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 40 Sayı: 10
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1093/jjco/hyq085
  • Dergi Adı: JAPANESE JOURNAL OF CLINICAL ONCOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.989-991
  • Anahtar Kelimeler: porphyria, trastuzumab, docetaxel, photosensitive reactions
  • Ankara Üniversitesi Adresli: Evet

Özet

Docetaxel (Taxotere), an anticancer agent, is known to cause various reactions, including hypersensitivity, oedema, skin toxicity with erythrodysesthesia syndrome, infusion site reactions, alopecia, nail onycholysis, nail pigmentation, photosensitivity, scleroderma and stomatitis. However, of all the reported effects, photosensitivity has only rarely been described in the literature. We experienced a case of cutaneous photosensitivity with aberrations in porphyrin biosynthesis that developed 1 month after the patient received combination chemotherapy consisting of docetaxel and trastuzumab. The eruption resolved with sun avoidance and discontinuation of docetaxel therapy. To our knowledge, this is the first case of a photosensitive reaction with enhanced levels of porphyrins during docetaxel therapy.