Carotid intima-media thickness and arterial stiffness as early markers of atherosclerosis in pediatric celiac disease

Creative Commons License

Demir A. M., KULOĞLU Z., Yaman A., FİTOZ Ö. S., NERGİZOĞLU G., KANSU TANCA A.

TURKISH JOURNAL OF PEDIATRICS, cilt.58, sa.2, ss.172-179, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 58 Sayı: 2
  • Basım Tarihi: 2016
  • Doi Numarası: 10.24953/turkjped.2016.02.008
  • Dergi Adı: TURKISH JOURNAL OF PEDIATRICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.172-179
  • Anahtar Kelimeler: celiac disease, children, atherosclerosis, carotid intima media thickness, pulse wave velocity, PULSE-WAVE VELOCITY, GLUTEN-FREE DIET, CARDIOVASCULAR RISK, POPULATION, MORTALITY, CHILDREN, PROFILE, EVENTS, ADULTS
  • Ankara Üniversitesi Adresli: Evet

Özet

The association between pediatric celiac disease (CD) and atherosclerosis is unknown. Our aim was to investigate whether pediatric CD patients have an increased risk of atherosclerosis. We evaluated the premature atherosclerosis by pulse wave velocity (PWV) and carotid intima-media thickness (cIMT). A total of 37 CD patients (20 girls, mean age 13 +/- 3.3 years) and 36 healthy age and sex matched controls were enrolled. Mean duration of CD was 47.1 +/- 32.3 months and 40.5% of patients had positive tissue transglutaminase antibody (tTg) IgA. Total cholesterol level was lower in CD (p= 0.026) and cIMT was lower in tTg IgA antibody negative CD (p= 0.030). cIMT was significantly correlated with tTg IgA antibody positivity (r= 0.336; p= 0.042). Adherence to strict gluten-free diet is associated with decreased cIMT, suggesting that gluten withdrawal seems to have a beneficial effect on premature atherosclerosis.