Mesenchymal Stem Cells for Coronavirus (COVID-19)-Induced Pneumonia: Revisiting the Paracrine Hypothesis with New Hopes?

Öztürk S., Elçin A. E., Elçin Y. M.

AGING AND DISEASE, cilt.11, sa.3, ss.477-479, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Editöre Mektup
  • Cilt numarası: 11 Sayı: 3
  • Basım Tarihi: 2020
  • Doi Numarası: 10.14336/ad.2020.0403
  • Dergi Adı: AGING AND DISEASE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, EMBASE, Directory of Open Access Journals
  • Sayfa Sayıları: ss.477-479
  • Anahtar Kelimeler: COVID-19, mesenchymal stem cells, cell transplantation, pneumonia, immunomodulation
  • Ankara Üniversitesi Adresli: Evet

Özet

Mesenchymal stem cells (MSCs) bear a promising potential for regenerative medicine therapies and they repair damaged tissue through secretion of immune modulatory and anti-inflammatory molecules acting in a paracrine fashion. Coronavirus disease 2019 (COVID-19) has spread all over the world with high morbidity and mortality rates and there is no specific treatment for this infection. A recent study published in the journal reports that MSC infusion is safe and effective in patients suffering from COVID-19 induced pneumonia. In the light of this study and previous reports, we make additional comments about possible therapeutic effects of MSCs in COVID-19 infection.