Role of Onabotulinum Toxin-A Injection in the Management of Pain and Sexual Dysfunction in Women with BPS/IC

Karaburun M. C., GÜLPINAR Ö.

Current Bladder Dysfunction Reports, vol.18, no.4, pp.369-373, 2023 (ESCI) identifier

  • Publication Type: Article / Review
  • Volume: 18 Issue: 4
  • Publication Date: 2023
  • Doi Number: 10.1007/s11884-023-00715-5
  • Journal Name: Current Bladder Dysfunction Reports
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, EMBASE
  • Page Numbers: pp.369-373
  • Keywords: Bladder Pain, Bladder Pain Syndrome, Interstitial Cystitis, Onabotulinum Toxin-A, Sexual Dysfunction, Women
  • Ankara University Affiliated: Yes

Abstract

Purpose of Review: In this review, we aimed to summarize the effects of BoNT-A injections on pain and sexual dysfunction in women with BPS/IC in the light of current literature. Recent Findings: In recent years, randomized controlled studies have provided evidence for the positive effects of intravesical BoNT-A treatment on pain and quality of life scores in patients with BPS/IC. Trigonal injections have demonstrated similar efficacy and safety to those administered to the bladder body. Furthermore, noninvasive alternatives such as low-energy shock wave plus intravesical instillation, hydrogel-based instillation, and liposome-encapsulated BoNT-A instillations have been explored for patients with BPS/IC. The studies examining the impact of BoNT-A on sexual functions are limited. Only one published study has shown improvement in sexual functions with intravesical BoNT-A. Summary: Intravesical BoNT-A treatment in BPS/IC patients is an effective and safe method recommended by the guidelines. In the light of current literature, this treatment also provides an improvement in sexual functions.