Antioxidant superoxide dismutase activity in obese children

Erdeve Ö., ŞIKLAR Z., Kocaturk P., Dallar Y., Kavas G.

BIOLOGICAL TRACE ELEMENT RESEARCH, cilt.98, sa.3, ss.219-227, 2004 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 98 Sayı: 3
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1385/bter:98:3:219
  • Dergi Adı: BIOLOGICAL TRACE ELEMENT RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.219-227
  • Anahtar Kelimeler: obesity, children, superoxide dismutase, glucose, cholesterol, triglyceride, C-REACTIVE PROTEIN, LIPID-PEROXIDATION, OXIDATIVE STRESS, HUMAN-DISEASE, FREE-RADICALS, GLUTATHIONE-PEROXIDASE, ADIPOSE-TISSUE, ENZYMES
  • Ankara Üniversitesi Adresli: Evet

Özet

The aim of the study was to evaluate the antioxidative Cu/Zn-SOD (superoxide dismutase) response to obesity-related stress in obese children compared to a similar-aged control group. Forty-eight exogenic obese children and 11 healthy children were compared for red cell Cu/Zn-SOD, glucose, and lipid profiles and the relations between them were investigated. Antioxidant response as Cu/Zn-SOD was significantly higher in the obese group (p<0.05). Although glucose and lipid levels were statistically higher in the obese group, a certain relation with the SOD level was not established in childhood. This is the first study showing the oxidative stress caused by obesity and related antioxidative response even in the childhood period. Interventions, including diet modifications, should be kept in mind to diminish the obesity-related oxidative stress from the childhood period.