Antioxidant superoxide dismutase activity in obese children
BIOLOGICAL TRACE ELEMENT RESEARCH, vol.98, no.3, pp.219-227, 2004 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 98 Issue: 3
- Publication Date: 2004
- Doi Number: 10.1385/bter:98:3:219
- Journal Name: BIOLOGICAL TRACE ELEMENT RESEARCH
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.219-227
- Keywords: obesity, children, superoxide dismutase, glucose, cholesterol, triglyceride, C-REACTIVE PROTEIN, LIPID-PEROXIDATION, OXIDATIVE STRESS, HUMAN-DISEASE, FREE-RADICALS, GLUTATHIONE-PEROXIDASE, ADIPOSE-TISSUE, ENZYMES
- Ankara University Affiliated: Yes
Abstract
The aim of the study was to evaluate the antioxidative Cu/Zn-SOD (superoxide dismutase) response to obesity-related stress in obese children compared to a similar-aged control group. Forty-eight exogenic obese children and 11 healthy children were compared for red cell Cu/Zn-SOD, glucose, and lipid profiles and the relations between them were investigated. Antioxidant response as Cu/Zn-SOD was significantly higher in the obese group (p<0.05). Although glucose and lipid levels were statistically higher in the obese group, a certain relation with the SOD level was not established in childhood. This is the first study showing the oxidative stress caused by obesity and related antioxidative response even in the childhood period. Interventions, including diet modifications, should be kept in mind to diminish the obesity-related oxidative stress from the childhood period.