Cardiovascular hypertrophy and increased vascular contractile responsiveness following repeated cocaine administration in rabbits

Sutliff R., Cai G., GÜRDAL H., Snyder D., Roberts J., Johnson M.

LIFE SCIENCES, cilt.58, sa.8, ss.675-682, 1996 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 58 Sayı: 8
  • Basım Tarihi: 1996
  • Doi Numarası: 10.1016/0024-3205(95)02336-4
  • Dergi Adı: LIFE SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.675-682
  • Anahtar Kelimeler: cocaine, hypertrophy, fos, blood vessel, contraction, LEFT-VENTRICULAR HYPERTROPHY, RAT NUCLEUS-ACCUMBENS, EARLY GENE-EXPRESSION, SMOOTH-MUSCLE CELLS, C-FOS, PROTOONCOGENE EXPRESSION, SUDDEN-DEATH, HYPERTENSION, ACTIVATION, RECEPTORS
  • Ankara Üniversitesi Adresli: Evet

Özet

The effects of repeated cocaine administration on contractile responses were studied in adult rabbits. Repeated cocaine exposure caused a significant increase in the maximal response of the aorta to the agonists norepinephrine and serotonin as well as the receptor-independent stimulus KCl when compared to the saline controls. Cocaine exposure caused a significant increase in the wet weights of both the heart and aorta. When the contraction was normalized to the wet weight of the aorta there was no difference between rabbits administered cocaine and saline. Acute cocaine administration caused a time-dependent increase in immunoreactivity of the proto-oncogene c-Fos in the aorta. These results show that repeated cocaine administration leads to the development of cardiovascular hypertrophy.