Pathologist's puzzle: Membranoproliferative glomerulonephritis-like features in cryoglobulinemic glomerulonephritis

KİREMİTCİ S., Calayoglu R., ENSARİ A., Erbay B.

PATHOLOGY RESEARCH AND PRACTICE, cilt.208, sa.4, ss.254-258, 2012 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 208 Sayı: 4
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1016/j.prp.2012.01.006
  • Dergi Adı: PATHOLOGY RESEARCH AND PRACTICE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.254-258
  • Anahtar Kelimeler: Cryoglobulinemia, Glomerulonephritis, Hepatitis C infection, HEPATITIS-C VIRUS, MIXED CRYOGLOBULINEMIA, POLYARTERITIS-NODOSA, RENAL INVOLVEMENT, INFECTION, VASCULITIS, DISEASE, LUPUS
  • Ankara Üniversitesi Adresli: Evet

Özet

Mixed cryoglobulinemia is commonly related to chronic HCV infection, and renal complications occur frequently. Typical renal involvement presents with diffuse proliferative glomerular pathology, similar to membranoproliferative glomerulonephritis, with necrotizing arteritis of medium-sized vessels, referred to as cryoglobulinemic glomerulonephritis. However, the histological appearance may vary according to the clinical presentation and treatment applied. Not only membranoproliferative glomerulonephritis but also certain types of systemic vasculitis (Systemic Lupus Erythematosus, Polyarteritis Nodosa), thrombotic microangiopathy, and Waldenstrom's Macroglobulinemia may exhibit similar histopathological findings in the biopsy with cryoglobulinemic glomerulonephritis. For an optimal differential diagnosis, clinicopathological correlation and serological findings should accompany the pathological findings. We present a case of cryoglobulinemic glomerulonephritis, and discuss the differential diagnosis in detail. (C) 2012 Elsevier GmbH. All rights reserved.