Akademik Veri Yönetim Sistemi
CARDIOVASCULAR ULTRASOUND, 2009 (SCI-Expanded)
Background: Endothelial dysfunction is thought to be a potential mechanism for the decreased presence of coronary collaterals. The aim of the study was to investigate the association between systemic endothelial function and the extent of coronary collaterals. Methods: We investigated the association between endothelial function assessed via flow mediated dilation (FMD) of the brachial artery following reactive hyperemia and the extent of coronary collaterals graded from 0 to 3 according to Rentrop classification in a cohort of 171 consecutive patients who had high grade coronary stenosis or occlusion on their angiograms. Results: Mean age was 61 years and 75% were males. Of the 171 patients 88 (51%) had well developed collaterals ( grades of 2 or 3) whereas 83 (49%) had impaired collateral development ( grades of 0 or 1). Patients with poor collaterals were significantly more likely to have diabetes ( p = 0.001), but less likely to have used statins ( p = 0.083). FMD measurements were not significantly different among good and poor collateral groups (11.5 +/- 5.6 vs. 10.4 +/- 6.2% respectively, p = 0.214). Nitroglycerin mediated dilation was also similar ( 13.4 +/- 5.9 vs. 12.8 +/- 6.5%, p = 0.521). Conclusion: No significant association was found between the extent of angiographically visible coronary collaterals and systemic endothelial function assessed by FMD of the brachial artery.