The inverse association between ANGPTL8 and PI3K-mTOR-PPARγ expressions in adipose tissue of high-fructose-fed rats: The modulatory effect of kefir

AKAR F., GÜNEY C., ÖZER H. B., PEKTAŞ M. B., KOCA H. B., KOCABAŞ A., ...Daha Fazla

Istanbul Journal of Pharmacy, cilt.51, sa.3, ss.299-306, 2021 (ESCI) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 51 Sayı: 3
  • Basım Tarihi: 2021
  • Doi Numarası: 10.26650/istanbuljpharm.2021.933139
  • Dergi Adı: Istanbul Journal of Pharmacy
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.299-306
  • Anahtar Kelimeler: Dietary fructose, Kefir, ANGPTL8, PI3K-mTOR-PPAR gamma pathway, Lipogenesis, CAUSES INSULIN-RESISTANCE, PHOSPHATIDYLINOSITOL 3-KINASE, SIGNALING PATHWAY, LIVER, ADIPOCYTES, PROTEIN, FAT, STIMULATION, BETATROPHIN, LIPOGENESIS
  • Ankara Üniversitesi Adresli: Evet

Özet

Background and Aims: The dietary high-fructose intake might be a risk factor for several metabolic diseases. Kefir, a fermented milk product, has been proposed to have beneficial health effects. In this study, we aimed to investigate the effects of fructose consumption and kefir supplementation on the lipogenesis-related genes including angiopoietin-like protein 8 (angptl8), phosphoinositide 3-kinase (pi3k), mammalian target of rapamycin (mtor), and peroxisome proliferator-activated receptor gamma (ppar gamma) as well as inflammatory factors in the adipose tissue to provide new mechanistic insights into lipogenesis.