Akademik Veri Yönetim Sistemi
COMPTES RENDUS DE L ACADEMIE BULGARE DES SCIENCES, cilt.76, sa.1, ss.128-137, 2023 (SCI-Expanded)
This study aims to compare the remineralization efficiency of grape seed extract versus fluoride in artificial carious dentin lesions in the biomimetic rem-ineralization procedure. One hundred and twelve extracted impacted human teeth were demineralized for 10 days and divided into 4 groups. Demineraliza-tion group (DM), remineralization group (RM group), remineralization fluoride group (RM F), remineralization grape seed extract group (RM GSE). Deminer-alization (DM) group were stored in physiological saline after demineralization. RM F was kept in 1000 ppm fluorine solution and RM GSE was kept in 6.5% grape seed extract for 10 min. RM, RM F, RM GSE groups were stored in simulated body fluid (SBF) with biomimetic analogues and Portland cement discs for 6 weeks. The specimens were evaluated by microhardness test, elastic-ity modulus measurement, and scanning electron microscope (SEM) analysis. Kruskal-Wallis H test with Bonferroni correction was used for between-group comparisons. Microhardness and elasticity modulus values differed significantly among the groups, with the highest values in the RM-GSE group, followed by the RM-F group, RM group, and DM group. SEM images showed granular structure formations in the RM-GSE and RM-F groups. It is concluded that although remineralization can occur by mineral precipitation in structures with high organic matrix density such as dentin, the collagen structure must be sup-ported to increase the degree of remineralization.