AGE-RELATED-CHANGES IN ANGIOTENSIN II-STIMULATED VASCULAR CONTRACTION AND INOSITOL PHOSPHATE ACCUMULATION IN FISCHER-344 RATS

CAI G., GÜRDAL H., SEASHOLTZ T., JOHNSON M.

MECHANISMS OF AGEING AND DEVELOPMENT, cilt.76, sa.2-3, ss.125-133, 1994 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 76 Sayı: 2-3
  • Basım Tarihi: 1994
  • Doi Numarası: 10.1016/0047-6374(94)91587-3
  • Dergi Adı: MECHANISMS OF AGEING AND DEVELOPMENT
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.125-133
  • Anahtar Kelimeler: AGE, ANGIOTENSIN II, VASCULAR CONTRACTION, INOSITOL PHOSPHATE, RECEPTOR, ANGIOTENSIN II, RATS, SMOOTH-MUSCLE CELLS, RECEPTOR SUBTYPES, AORTA, CALCIUM, NOREPINEPHRINE, TRISPHOSPHATE, REACTIVITY, EXPRESSION, RELAXATION, ARTERIES
  • Ankara Üniversitesi Adresli: Evet

Özet

This study examined the influence of age on angiotensin II (AII)-stimulated vascular contractile responses and inositol phosphate (IP) accumulation in Fischer 344 rats. In the aorta, AII-stimulated contraction and IP accumulation were markedly reduced in 6- and 24-month-old rats compared to 1-month-old rats. There was not a significant difference in the contractile response to AII between 6- and 24-month-old rats, although IP hydrolysis showed a further decrease between 6 and 24 months. In tail artery, there were no differences in contraction and phosphoinositol metabolism in response to AII in the different ages. Losartan blocked AII-stimulated vascular contraction and IP hydrolysis in both aorta and tail artery while PD123319 did not inhibit either response. These data indicate that during maturation, there is a decline in AII-stimulated aortic contraction and IP accumulation in aorta but not in tail artery and these changes are due to altered ATI receptor function.