Atıf İçin Kopyala
Utkan G., Urun Y., Cangir A., Oksuzoglu O. B., Özdemir N., Oztuna D. G., ...Daha Fazla
JOURNAL OF CLINICAL ONCOLOGY, cilt.30, sa.15_suppl, ss.1596-1597, 2012 (SCI-Expanded)
-
Yayın Türü:
Makale / Tam Makale
-
Cilt numarası:
30
Sayı:
15_suppl
-
Basım Tarihi:
2012
-
Doi Numarası:
10.1200/jco.2012.30.15_suppl.1596
-
Dergi Adı:
JOURNAL OF CLINICAL ONCOLOGY
-
Derginin Tarandığı İndeksler:
Science Citation Index Expanded (SCI-EXPANDED), Scopus
-
Sayfa Sayıları:
ss.1596-1597
-
Ankara Üniversitesi Adresli:
Evet
Özet
1596 Background: The role of genetic factors in the development of cancer is widely accepted. Previous studies have observed an association between ABO blood group and risk of certain malignancies, including pancreatic and gastric cancer. The data on the role of ABO blood group and Rh factor in lung cancer is limited. Methods: All patients who had Lung cancer (LC) and treated between 2000-2011 at the involved centers with defined ABO/Rh were included in our retrospective reviews of tumor registry records. A group of volunteer healthy blood donors of Turkish Red Crescent between 2004 and 2011 were identified as a control group. The relationship of ABO/Rh with clinical features such as age at diagnosis, histological subtype and sex were evaluated. We compared the distributions of ABO/Rh among 1954 patients and 3,022,883 controls. Among LC patients, differences between each of aforementioned ABO/Rh groups with respect to various clinical features were explored, respectively. Results: Of these patients the median age was 62 (range: 17-90). The 84% of patients were male. Overall distributions of ABO blood groups as well as Rh factor were statistically different between patients (43.6% A, 8.3% AB, 17.3% B, 30.8% O, and 86.3% Rh+) and controls (42.2% A, 7.6% AB, 16.3% B, 33.9% O, and 87.7% Rh+) (p=0,03). In addition, there were statistically significant differences between patients and controls with respect to O vs. nonO (p=0.004) and marginal significance for A vs. nonA (p=0,065), B vs. nonB (p=0,076), and Rh+ vs. Rh- (p=0,057). Among patients, there weren’t statistically significant differences between blood group with respect to sex and age. However there was statistically significant difference between blood group with respect to histology (p=0,001). Although the distribution of A and O were similar according to histology, patients with squamous histology had antigen B more frequently than other histological sub types (p=0,009). Conclusions: In the study populations, ABO blood type was statistically significantly associated with the LC and having blood type other than O increases the risk of LC. Further studies are necessary to define the mechanisms by which ABO blood type may influence breast cancer risk.