Endoplasmic Reticulum Stress and Obesity

YILMAZ E.

OBESITY AND LIPOTOXICITY, cilt.960, ss.261-276, 2017 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 960
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1007/978-3-319-48382-5_11
  • Dergi Adı: OBESITY AND LIPOTOXICITY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED)
  • Sayfa Sayıları: ss.261-276
  • Anahtar Kelimeler: Autophagy, Endoplasmic reticulum stress, Lipotoxicity, Obesity, Type 2 diabetes, UNFOLDED PROTEIN RESPONSE, INDUCED INSULIN-RESISTANCE, PANCREATIC BETA-CELLS, THIOREDOXIN-INTERACTING PROTEIN, NECROSIS-FACTOR-ALPHA, NF-KAPPA-B, ER-STRESS, TRANSLATIONAL CONTROL, CHEMICAL CHAPERONES, DIABETES-MELLITUS
  • Ankara Üniversitesi Adresli: Evet

Özet

In recent years, the world has seen an alarming increase in obesity and closely associated with insulin resistance which is a state of low-grade inflammation, the latter characterized by elevated levels of proinflammatory cytokines in blood and tissues. A shift in energy balance alters systemic metabolic regulation and the important role that chronic inflammation, endoplasmic reticulum (ER) dysfunction, and activation of the unfolded protein response (UPR) play in this process.