mTOR and P70S6 kinase expression in primary liver neoplasms

ŞAHİN F., Kannangai R., Adegbola O., Wang J., Su G., Torbenson M.

CLINICAL CANCER RESEARCH, vol.10, no.24, pp.8421-8425, 2004 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 10 Issue: 24
  • Publication Date: 2004
  • Doi Number: 10.1158/1078-0432.ccr-04-0941
  • Journal Name: CLINICAL CANCER RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.8421-8425
  • Ankara University Affiliated: No

Abstract

Purpose: mTOR and P70 S6 kinase (S6K) play a key role in regulating protein translation. The role of mTOR and S6K in hepatocellular carcinoma has not been investigated, but this pathway is of particular interest because an effective inhibitor, rapamycin, is available. This study was undertaken to determine the prevalence and clinicopathological correlates of mTOR pathway activation in hepatocellular carcinoma and to determine whether rapamycin inhibits the pathway in cell culture.