An Experimental Study of Radiation Effect on Normal Tissue: Analysis of HIF-1 alpha, VEGF, eIF2, TIA-1, and TSP-1 Expression

Aktas C., KURTMAN C., ÖZBİLGİN M. K., Tek I., TOPRAK S. K.

TURKISH JOURNAL OF HEMATOLOGY, cilt.30, sa.4, ss.371-378, 2013 (SCI-Expanded, Scopus, TRDizin) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 30 Sayı: 4
  • Basım Tarihi: 2013
  • Doi Numarası: 10.4274/tjh.2012.0142
  • Dergi Adı: TURKISH JOURNAL OF HEMATOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.371-378
  • Anahtar Kelimeler: Angiogenesis, Radiation, Cancer and normal tissue, Vascular endothelium, HIP-1 alpha, VEGF, eIF2, TIA-1, TSP-1, IONIZING-RADIATION, STRESS GRANULES, TUMOR-GROWTH, HYPOXIA, INTERLEUKIN-8, ANGIOGENESIS, RADIOTHERAPY, ACTIVATION, APOPTOSIS, PATHWAYS
  • Ankara Üniversitesi Adresli: Evet

Özet

Objective: This study investigated whether or not the stress and hypoxia, which are the effects of radiation on normal vascular endothelium, leading to the release of HIF-1 alpha, VEGF, eIF2, TIA-1, and TSP-1 were related and the possibility of them stimulating angiogenesis.