An Experimental Study of Radiation Effect on Normal Tissue: Analysis of HIF-1 alpha, VEGF, eIF2, TIA-1, and TSP-1 Expression
TURKISH JOURNAL OF HEMATOLOGY, cilt.30, sa.4, ss.371-378, 2013 (SCI-Expanded, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 30 Sayı: 4
- Basım Tarihi: 2013
- Doi Numarası: 10.4274/tjh.2012.0142
- Dergi Adı: TURKISH JOURNAL OF HEMATOLOGY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.371-378
- Anahtar Kelimeler: Angiogenesis, Radiation, Cancer and normal tissue, Vascular endothelium, HIP-1 alpha, VEGF, eIF2, TIA-1, TSP-1, IONIZING-RADIATION, STRESS GRANULES, TUMOR-GROWTH, HYPOXIA, INTERLEUKIN-8, ANGIOGENESIS, RADIOTHERAPY, ACTIVATION, APOPTOSIS, PATHWAYS
- Ankara Üniversitesi Adresli: Evet
Özet
Objective: This study investigated whether or not the stress and hypoxia, which are the effects of radiation on normal vascular endothelium, leading to the release of HIF-1 alpha, VEGF, eIF2, TIA-1, and TSP-1 were related and the possibility of them stimulating angiogenesis.