Is CD117 Expression Related with Plasma Cell Differentiation, IRF4/MUM1 and CD38 Expressions in Lymphoid Neoplasms?

Kaygusuz G., KUZU I., KİREMİTCİ S., Kankaya D., Biyikli Z.

TURKISH JOURNAL OF MEDICAL SCIENCES, sa.6, ss.511-517, 2008 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Basım Tarihi: 2008
  • Dergi Adı: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.511-517
  • Anahtar Kelimeler: CD117 expression. lymphoma, CD38 reactivity, plasma cell differentiation, IRF4/MUM1 expression, C-KIT EXPRESSION, HODGKINS-DISEASE, TISSUE MICROARRAY, MULTIPLE-MYELOMA, MUM1/IRF4, IMMUNOHISTOCHEMISTRY, OVEREXPRESSION, DIAGNOSIS, MOLECULE, RECEPTOR
  • Ankara Üniversitesi Adresli: Evet

Özet

Aim: In this study, we aimed to assess the expression of CD117 in a large series of both Hodgkin's and non-Hodgkin's lymphoma, and to investigate the association between the expression patterns of CD117, IRF4/MUM1, and CD38. Materials and Methods: A total of 237 lymphoma cases were selected and examined within six tissue microarray paraffin blocks. Immunohistochemistry was performed using antibodies against CD117. lRF4/MUM1 and CD38. Results: CD117 and IRF4/MUM1 immunoreactivity were seen in a subset of high-grade and low-grade B-cell lymphomas, as well as T-cell lymphomas and classical type Hodgkin's lymphomas. CD38 positivity was only detected in 1% of diffuse large B-cell lymphoma and 66% of precursor B-lymphoblastic lymphoma. in addition to myeloma cases. CD117 expression was not correlated with IRF4/MUM1 expression (P > 0.05). Two of three CD38-positive cases were positive for CD117. Conclusions: These results suggest that CD117 expression can be seen in a subset of T- or B- cell lymphoid neoplasms and plasma cell myelomas. It seems that there is no relation between the expression of CD117 and plasma cell differentiation markers in lymphomas.