Paclitaxel-loaded niosomes for intravenous administration: pharmacokinetics and tissue distribution in rats

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SEZGİN BAYINDIR Z., BEŞİKCİ A., YÜKSEL N.

TURKISH JOURNAL OF MEDICAL SCIENCES, cilt.45, sa.6, ss.1403-1412, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 45 Sayı: 6
  • Basım Tarihi: 2015
  • Doi Numarası: 10.3906/sag-1408-129
  • Dergi Adı: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.1403-1412
  • Anahtar Kelimeler: Niosomes, Span 40, paclitaxel, pharmacokinetics, tissue distribution, TARGETED DRUG-DELIVERY, ACTIVATED MACROPHAGES, BOLA-SURFACTANT, EFFICACY, PEG, ENHANCEMENT, COMBINATION, CISPLATIN, MICELLES, SYSTEMS
  • Ankara Üniversitesi Adresli: Evet

Özet

Background/aim: The purpose of this study was to investigate and compare the pharmacokinetic behavior and tissue distribution of paclitaxel, delivered as commercial preparation Taxol or through Span 40 niosomes, after intravenous injection to rats.