Pharmacological Applications of Nrf2 Inhibitors as Potential Antineoplastic Drugs

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Telkoparan-Akillilar P., SÜZEN S., Saso L.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, cilt.20, sa.8, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 20 Sayı: 8
  • Basım Tarihi: 2019
  • Doi Numarası: 10.3390/ijms20082025
  • Dergi Adı: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: Nrf2 inhibitors, antineoplastic drugs, cancer, chemoresistance, cancer chemoprevention and therapy, TRANSCRIPTION FACTOR NRF2, OXIDATIVE STRESS, SIGNALING PATHWAY, GENE-EXPRESSION, LUNG-CANCER, KEAP1 GENE, INCREASED SUSCEPTIBILITY, MOLECULAR-MECHANISMS, NRF2-DEFICIENT MICE, NEGATIVE REGULATION
  • Ankara Üniversitesi Adresli: Evet

Özet

Oxidative stress (OS) is associated with many diseases ranging from cancer to neurodegenerative disorders. Nuclear factor-erythroid 2 p45-related factor 2 (Nrf2) is one of the most effective cytoprotective controller against OS. Modulation of Nrf2 pathway constitutes a remarkable strategy in the antineoplastic treatments. A big number of Nrf2-antioxidant response element activators have been screened for use as chemo-preventive drugs in OS associated diseases like cancer even though activation of Nrf2 happens in a variety of cancers. Research proved that hyperactivation of the Nrf2 pathway produces a situation that helps the survival of normal as well as malignant cells, protecting them against OS, anticancer drugs, and radiotherapy. In this review, the modulation of the Nrf2 pathway, anticancer activity and challenges associated with the development of an Nrf2-based anti-cancer treatment approaches are discussed.