Synthesis and In vitro Antimicrobial Activity of Novel 2-(4-(Substituted-carboxamido)benzyl/phenyl)benzothiazoles

Yilmaz S., Yalcin I., Kaynak-Onurdag F., Ozgen S., YILDIZ İ., Aki E.

CROATICA CHEMICA ACTA, cilt.86, sa.2, ss.223-231, 2013 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 86 Sayı: 2
  • Basım Tarihi: 2013
  • Doi Numarası: 10.5562/cca2064
  • Dergi Adı: CROATICA CHEMICA ACTA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.223-231
  • Anahtar Kelimeler: benzothiazole, antibacterial activity, antifungal activity, multi-drug resistance, TOPOISOMERASE-II INHIBITORS, ANTITUMOR BENZOTHIAZOLES, BENZAZOLE DERIVATIVES, RESISTANCE, 3D-QSAR
  • Ankara Üniversitesi Adresli: Evet

Özet

A new series of 2-[4-(4-substitutedbenzamido / phenylacetamido / phenylpropionamido) benzyl / phenyl]benzothiazole derivatives (6a-6w) were synthesized and evaluated for antibacterial and antifungal activities against Staphylococcus aureus, Bacillus subtilis, Klebsiella pneumoniae, Pseudomonas aeruginosa, Escherichia coli with their drug-resistant isolates and a yeast Candida albicans. Microbiological results indicated that the compounds possessed a broad spectrum of activity against the tested microorganisms at MIC values between 200 and 6.25 mu g/ml. Compounds 6e and 6j exhibited the greatest activity with MIC values of 6.25 mu g/ml against Pseudomonas aeruginosa, and Staphylococcus aureus isolate, respectively.