Synthesis and antidiabetic activity of some new chromonyl-2,4-thiazolidinediones

Bozdag-Duendar O., Ceylan-Uenluesoy M., Verspohl E. J., Ertan R.

ARZNEIMITTELFORSCHUNG-DRUG RESEARCH, cilt.57, sa.8, ss.532-536, 2007 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 57 Sayı: 8
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1055/s-0031-1296644
  • Dergi Adı: ARZNEIMITTELFORSCHUNG-DRUG RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Index Chemicus (IC)
  • Sayfa Sayıları: ss.532-536
  • Anahtar Kelimeler: antidiabetic agents, chromone, chromonyl-2,4-thiazolidine-diones, antidiabetic activity, synthesis, 2,4-thiazolidinediones, AGENT CS-045
  • Ankara Üniversitesi Adresli: Evet

Özet

A series of chromonyl-2,4-thiazolidinediones (VIa-f) and chromonyl-2,4-imidazolidinediones (VIIa-f) was prepared by Knoevenagel reaction of substituted benzyl-2,4-thiazolidinediones (IVa-f) and substituted benzyl-2,4-imidazolidinediones (IVa-f) with chromone-3-carboxaldehyde (I). The prepared compounds were tested for their insulinotropic activities in INS-1 cells. Compounds Via, VIb, Vid and VIIe (at lower concentration; 1 mu g/ml) were able to increase insulin release in the presence of 5.6 mmol/l glucose; their effects were lower than that of glibenclamide (CAS 10238-21-8). The activity of the most potent compound (VId) was still 9% less than that of glibenclamide.