MDR1 gene single nucleotide polymorphisms in cancer pharmacogenetics Kanser farmakogenetiǧinde MDR1 geni tek nükleotid polimorfizmleri

GÜMÜŞ AKAY G.

Turkiye Klinikleri Journal of Medical Sciences, cilt.30, sa.3 SUPPL., 2010 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 30 Sayı: 3 SUPPL.
  • Basım Tarihi: 2010
  • Dergi Adı: Turkiye Klinikleri Journal of Medical Sciences
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: P-glycoprotein, Pharmacogenetics
  • Ankara Üniversitesi Adresli: Evet

Özet

Human MDR1 gene encoding P-glycoprotein (P-gp) plays an important role in multidrug resistance to chemotherapeutic agents as well as affects the pharmacokinetics of many drugs and xenobiotics. To date, over 60 single nucleotide polymorphisms (SNPs) have been reported for the coding region of MDR1 gene, some of which can affect P-gp expression and function. However, the effect of these polymorphisms on P-gp function and their clinical impact are in most cases unclear. In this review, three most common MDR1 SNPs (C1236T, G2677T/A and C3435T) and their potential implications for cancer pharmacogenetics are summarized. © 2010 by Türkiye Klinikleri.