Energy deposition responses, transmission factors, and radiation interaction properties of some antibiotics: A critical assessment for substantial molecular alterations as a function of radiation exposure

Almansoori A., Almisned G., Sen Baykal D., KILIÇ C. S., Tekin H.

Radiation Physics and Chemistry, cilt.216, 2024 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 216
  • Basım Tarihi: 2024
  • Doi Numarası: 10.1016/j.radphyschem.2023.111473
  • Dergi Adı: Radiation Physics and Chemistry
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, Chemical Abstracts Core, Chimica, Communication Abstracts, Compendex, INSPEC, Metadex, Pollution Abstracts, Civil Engineering Abstracts
  • Anahtar Kelimeler: Antibiotics, Deposited energy, Drug, Monte Carlo, Pharmaceuticals, Radiation interaction
  • Ankara Üniversitesi Adresli: Evet

Özet

This study addresses the underexplored area of radiation interaction properties of antibiotics and their implications for stability, efficacy, and structural integrity. Focusing on a range of antibiotics classified by the United Arab Emirates National AMR Surveillance system, the research evaluates key metrics such as attenuation coefficients, effective electron density, exposure buildup factor, and photon transmission factors. Utilizing advanced MCNPX Monte Carlo simulation, we observed varied interaction patterns among different antibiotics, with significant findings on their photon interaction characteristics. The study highlights the potential molecular changes in antibiotics due to radiation exposure, emphasizing the importance of such research in fields from medical radiography to space exploration. Results indicate that radiation exposure can significantly affect antibiotic properties, underscoring the need for careful evaluation of drugs in radiation-rich environments to ensure their effectiveness and safety.