Synthesis and antioxidant properties of novel N-H and N-substituted propanamide derivatives

Olgen S., Kilic Z., Ada A. O., Coban T.

Archiv der Pharmazie, cilt.340, sa.3, ss.140-146, 2007 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 340 Sayı: 3
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1002/ardp.200600176
  • Dergi Adı: Archiv der Pharmazie
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.140-146
  • Anahtar Kelimeler: indole-3-propionic acid, inhibition, lipid peroxidation, superoxide dismutase, synthesis, INDOLE-DERIVATIVES, SERIES, OXIDATION
  • Ankara Üniversitesi Adresli: Evet

Özet

The interest in the application of antioxidants for medical treatment has been growing recently. A lot of evidence has proven the link between the development of human diseases and oxidative stress. Indole derivatives were found to be very effective in protecting against oxidative stress. Recent exciting findings have demonstrated that several indole derivatives (IDs) are strong inhibitors of superoxide anion (SOD) and lipid peroxidation (LP). In this study, a series of novel N-H and N-substituted indole-3-propanamide derivatives (I3PADs) have been prepared and their efficiencies were investigated towards SOD and LP. Among the synthesized I3PADs, compounds 5 and 7-12 significantly inhibited O2•- in the range of 94-100%. In addition, N-H I3PADs showed a stronger inhibitory effect (compounds 1-5, 56-83%) on lipid peroxidation levels than SOD. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.