Effect of PDYN and OPRK1 polymorphisms on the risk of alcohol use disorder and the intensity of depressive symptoms

Ozkan-Kotiloglu S., AKYÜZLÜ D., Yurdakul R., Yildirim M. A., Ozgur-Ilhan İ.

ALCOHOL AND ALCOHOLISM, cilt.58, sa.4, ss.404-414, 2023 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 58 Sayı: 4
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1093/alcalc/agad036
  • Dergi Adı: ALCOHOL AND ALCOHOLISM
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus, Academic Search Premier, ASSIA, PASCAL, Animal Behavior Abstracts, BIOSIS, CAB Abstracts, CINAHL, Educational research abstracts (ERA), EMBASE, Food Science & Technology Abstracts, MEDLINE, Psycinfo, Social services abstracts, Sociological abstracts, Veterinary Science Database
  • Sayfa Sayıları: ss.404-414
  • Anahtar Kelimeler: alcohol use disorder, kappa-opioid receptor, individual difference, OPRK1 rs6473797, OPRK1 rs963549, OPIOID RECEPTOR GENE, MESSENGER-RNA STABILITY, NOR-BINALTORPHIMINE, DRUG-DEPENDENCE, ASSOCIATION, ANTAGONIST, DRINKING, SYSTEM, COMORBIDITY, NALTREXONE
  • Ankara Üniversitesi Adresli: Evet

Özet

Short Summary: OPRK1 rs6473797 CC genotype was found to lead to a 3.11 times greater alcohol dependence risk. OPRK1 rs963549 CC genotype was associated with the intensity of depressive symptoms. PDYN rs2281285, rs2225749 and rs910080 were not associated with the risk of AUD in males.